During the early phases of the Covid-19 pandemic, the possibility emerged that the use of the pain reliever ibuprofen could lead to a more severe course of coronavirus disease.
The use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and diclofenac, is not associated with any adverse effects in people with Covid-19, the disease that causes the new coronavirus, according to a study carried out by researchers from the University of Southern Denmark, Aarhus University Hospital and the Danish Medicines Agency.
During the early phases of the Covid-19 pandemic, the possibility arose that the use of the pain reliever ibuprofen could lead to a more severe course of coronavirus disease. Since the use of ibuprofen and other NSAIDs is widespread, data on their safety are urgently needed to guide clinicians and patients.
In the new study, published in the journal PLOS Medicine, researchers obtained data on the 9,326 Danish residents who tested positive for Covid-19 between February 27, 2020, and April 29, 2020. The data showed the use of NSAIDs, mortality at 30 days, hospitalization, ICU admission, mechanical ventilation, and acute renal replacement therapy.
The researchers found no association between any of the results and the use of NSAIDs. Additionally, among NSAID users in a matched cohort who tested positive for coronavirus, 6.3% died, 24.5% were hospitalized, and 4.9% were admitted to the ICU.
Of those who tested positive for the coronavirus but were not treated with NSAIDs, 6.1% died, 21.2% were hospitalized, and 4.7% were admitted to the ICU. None of these differences between the groups was statistically significant.
“Given the available evidence, there is no reason to withdraw the well-indicated use of NSAIDs during the SARS-CoV-2 pandemic. However, the well-established adverse effects of NSAIDs, particularly their effects, should always be considered. renal, gastrointestinal and cardiovascular, and NSAIDs should be used in the lowest possible dose for the shortest possible time for all patients, “have settled the experts.